Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis
نویسندگان
چکیده
منابع مشابه
Red cells, hemoglobin, heme, iron, and atherogenesis.
OBJECTIVE We investigated whether red cell infiltration of atheromatous lesions promotes the later stages of atherosclerosis. METHODS AND RESULTS We find that oxidation of ferro (FeII) hemoglobin in ruptured advanced lesions occurs generating ferri (FeIII) hemoglobin and via more extensive oxidation ferrylhemoglobin (FeIII/FeIV=O). The protein oxidation marker dityrosine accumulates in compli...
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Glucocorticoids are used extensively to treat autoimmune hemolytic anemias. Some beneficial effects of glucocorticoid pulse therapy have also been reported in sickle cell disease and paroxysmal nocturnal hemoglobinuria. Based on established concepts of hemoglobin (Hb) toxicity and physiologic Hb scavenger systems, we evaluated whether glucocorticoids could support an adaptive response to extrac...
متن کاملRadio-iron in Plasma Does Not Exchange with Hemoglobin Iron in Red Cells.
Marihuana: PROFESSOR ROGER ADAMS ....................................... 115 Special Articles: Radio-iron in Plasma Does Not Exchange with The Royal Society of Canada: PROFESSOR D. A. KEYS 119 Hemoglobin Iron in Red Cells: DR. G. H. WHIPPLE and OTHERS. Viscosity and the Shape of Protein Scientific Events: Molecules: DRS. J. W. MEHL, J. L. ONCLEY and Chem istry Exhibits of the Chicago useum of S...
متن کاملIntestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase.
Hemoglobin and myoglobin are a major source of dietary iron in man. Heme, separated from these hemoproteins by intraluminal proteolysis, is absorbed intact by the intestinal mucosa. The absorbed heme is cleaved in the mucosal cell releasing inorganic iron. Although this mucosal heme-splitting activity initially was ascribed to xanthine oxidase, we investigated the possibility that it is catalyz...
متن کاملRED CELLS, IRON, AND ERYTHROPOIESIS Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification
Detoxification and clearance of extracellular hemoglobin (Hb) have been attributed to its removal by the CD163 scavenger receptor pathway. However, even lowlevel hydrogen peroxide (H2O2) exposure irreversibly modifies Hb and severely impairs Hb endocytosis by CD163. We show here that when Hb is bound to the highaffinity Hb scavenger protein haptoglobin (Hp), the complex protects Hb from structu...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2010
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.206433